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The number of protons in the atomic nucleus (atomic number) is the defining characteristic of each element; different isotopes of the same element differ in the number of neutrons only. Despite the immense variation and number of substances, there are only some different stable elements.

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Stable even–even nuclides number as many as three isobars for some mass numbers, and up to seven isotopes for some atomic numbers. Conversely, of the known stable nuclides, only five have both an odd number of protons and odd number of neutrons: hydrogen-2, lithium-6, boron, nitrogen, and tantalumm.